Availability: In Stock
TB-500
Price range: $59.99 through $84.99
TB-500 is a synthetic thymosin beta-4 fragment studied for systemically mobile tissue repair across wound healing, cardiovascular, and musculoskeletal models.
Earn $2 Cenexa Bucks when you buy this product!Availability: In Stock
A portion of every order supports organizations focused on children’s cancer research & care. Help us make a difference.
Buy More & Save!
Add selected quantity to cart above & discount is automatically applied.
Quick Links
TB-500 Peptide
The Systemically Mobile Tissue Repair Peptide
Also known as: Thymosin Beta-4 Fragment, Ac-LKKTETQ
Why Researchers Choose TB-500
Unlike many repair peptides that stay localized at the application site, TB-500 has an exceptionally low molecular weight and doesn’t bind to the extracellular matrix—allowing it to travel systemically through tissues to reach distant injury sites. This unique mobility makes it valuable for studying whole-body repair mechanisms and comparing localized versus systemic healing responses across multiple tissue types.
What It Is
TB-500 is a synthetic acetylated fragment of thymosin beta-4, a naturally abundant protein found in nearly all mammalian cells except red blood cells. Originally isolated from the thymus gland, the full thymosin beta-4 molecule is one of the most prevalent proteins in cells—comprising up to 10% of total cellular protein content.
Researchers became interested when studies revealed that this small peptide could influence fundamental cellular processes like migration, survival, and blood vessel formation—effects that appeared to translate across diverse tissue types from heart muscle to skin to neural tissue.
How It Works (What Makes It Interesting)
Studies suggest TB-500 peptide may influence tissue repair through several interconnected mechanisms:
Actin regulation – Sequesters G-actin monomers (the building blocks of the cellular cytoskeleton), controlling how cells maintain structure and move toward injury sites
Cell survival signaling – Activates the ILK/Akt pathway, a key cellular survival mechanism that helps prevent programmed cell death in damaged tissues
Angiogenesis promotion – Upregulates VEGF (vascular endothelial growth factor) expression and promotes new blood vessel formation, increasing nutrient and oxygen delivery to healing areas
Collagen organization – Enhances both production and structural organization of collagen fibers, leading to more mature, organized tissue repair with reduced scarring
Migration enhancement – Stimulates keratinocyte (skin cells) and endothelial (blood vessel lining) cell migration through specific interactions with the actin cytoskeleton
Common Research Applications
Dermal Wound Healing: Surgical incisions, burn injuries, diabetic ulcers, post-operative wound closure, scar formation studies
Cardiovascular Research: Myocardial infarction models, cardiac tissue damage, heart muscle cell survival, post-ischemic recovery
Musculoskeletal Models: Muscle strains, ligament tears, tendon injuries, connective tissue repair, adhesion prevention studies
Ocular Applications: Corneal wounds, bacterial keratitis, UV-induced damage, chemical burn injuries, alkali exposure models
Neurological Research: Spinal cord injury, peripheral nerve regeneration, brain tissue repair, neuroprotection studies
Hair Follicle Research: Hair follicle stem cell activation, alopecia models, wound-associated hair growth, scalp circulation studies
What You’re Getting
Every batch of our TB-500 peptide meets rigorous research standards:
- Exceeds 99% Purity – Verified by HPLC analysis
- Certificate of Analysis (COA) – Included with every order, showing purity and identity confirmation
- Endotoxin-Free – Tested to ensure <1 EU/mg for cell culture applications
- Manufactured in USA – GMP-certified facilities with full traceability
- Sterile & Lyophilized – Stable for long-term storage, easy reconstitution
- Fast Shipping – Most orders ship same day. We offer flat rate shipping and 2-3 day delivery in the USA
Click the “Add To Cart” button to grab your TB-500 today!
TB-500 Research Overview
TB-500 is a synthetic, N-terminally acetylated seven-amino-acid peptide (Ac-LKKTETQ) that reproduces the actin-binding region of thymosin beta-4, a 43-amino-acid protein involved in cell migration and tissue repair. It was originally developed for veterinary research. Much of what is known about this region comes from studies of full-length thymosin beta-4, so the two should not be treated as interchangeable.
Technical Specifications
| CAS Number | 885340-08-9 |
|---|---|
| Molecular Formula | C38H68N10O14 |
| Molecular Weight | 889.02 g/mol |
| Amino Acid Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln |
| Half-Life (Plasma) | 0.95-2.1 hours (dose-dependent) |
| Stability | N-terminal acetylation provides enzymatic protection |
| Solubility | Water soluble; stable in saline solutions |
| Storage | Lyophilized: -20°C; Reconstituted: 2-8°C (stability varies by protocol) |
TB-500 corresponds to amino acids 17-23 of thymosin beta-4 and contains the conserved LKKTET actin-binding motif.
How TB-500 Is Thought to Work
- Actin binding. The LKKTET region binds G-actin monomers. This is the part of thymosin beta-4 linked to cell migration, and it can promote angiogenesis on its own [2][3].
- Active metabolites. A 2024 study measured TB-500 and its breakdown products in rats and cell assays. It found that the metabolite Ac-LKKTE, rather than TB-500 itself, showed the wound-healing activity [4].
Key Preclinical Findings
- Skin wound healing (thymosin beta-4). In a rat full-thickness wound model, full-length thymosin beta-4 increased reepithelialization by 42% at day 4 and 61% at day 7 compared with controls [1]. Later studies of thymosin beta-4 also reported faster dermal healing [5].
- Short active sequences. Short fragments of thymosin beta-4, including the actin-binding sequence, reproduced specific activities of the full protein, such as angiogenesis and wound healing [3].
- Heart and ligament (thymosin beta-4). Studies in mice and rats reported cardiac repair and ligament-healing effects with full-length thymosin beta-4 [6][7][8]. These have not been directly replicated with the TB-500 fragment.
Research Limitations
- No peer-reviewed human clinical trials exist for TB-500.
- Whether TB-500 reproduces the effects of full-length thymosin beta-4 across tissue types has not been established, and its breakdown products may account for some of its activity [4].
- Commercial products sold as “TB-500” have been found to vary in composition, including misbranded and adulterated material [9].
- Long-term safety has not been studied in any species.
Regulatory Status
TB-500 is not approved by the U.S. FDA for any human or veterinary use, and the FDA has issued warning letters to companies marketing it for human use. The World Anti-Doping Agency lists TB-500 as prohibited at all times under Section S2 (Peptide Hormones, Growth Factors, Related Substances, and Mimetics). Detection methods for anti-doping testing have been published [10].
Research Classification: TB-500 is available only for laboratory research use. It is not intended for human consumption, medical use, or veterinary applications.
References
- Malinda KM, Sidhu GS, Mani H, et al. (1999). Thymosin beta4 accelerates wound healing. J Invest Dermatol 113(3):364-368. PubMed
- Philp D, Huff T, Gho YS, Hannappel E, Kleinman HK. (2003). The actin binding site on thymosin beta4 promotes angiogenesis. FASEB J 17(14):2103-2105. PubMed
- Sosne G, Qiu P, Goldstein AL, Wheater M. (2010). Biological activities of thymosin beta4 defined by active sites in short peptide sequences. FASEB J 24(7):2144-2151. PubMed
- Rahaman KA, Muresan AR, Min H, et al. (2024). Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. J Chromatogr B 1235:124033. PubMed
- Treadwell T, Kleinman HK, Crockford D, et al. (2012). The regenerative peptide thymosin beta4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci 1270:37-44. PubMed
- Bock-Marquette I, Saxena A, White MD, et al. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432(7016):466-472. PubMed
- Smart N, Risebro CA, Melville AA, et al. (2007). Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445(7124):177-182. PubMed
- Xu B, Yang M, Li Z, et al. (2013). Thymosin beta4 enhances the healing of medial collateral ligament injury in rat. Regul Pept 184:1-5. PubMed
- Delcourt V, Garcia P, Chabot B, et al. (2023). TB500/TB1000 and SGF1000: A scientific approach for a better understanding of misbranded and adulterated drugs. Drug Test Anal 15(4):458-464. PubMed
- Ho EN, Kwok WH, Lau MY, et al. (2012). Doping control analysis of TB-500, a synthetic version of an active region of thymosin beta4, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A 1265:57-69. PubMed
These citations are provided for educational and research purposes only. This information is not intended to diagnose, treat, cure, or prevent any disease. TB-500 is intended for laboratory research use only.
When we run a peptide production batch, we produce all vial strengths (MG sizes) in the same run using the same raw material, lyophilization cycle, and fill/finish process.
This keeps quality consistent and costs under control.
Because all strengths come from the same production batch, they carry the same batch number, and the COA shown below applies to all MG sizes from that batch.
If a specific MG size is ever produced under a different batch number, its separate COA will be listed as well.
The Cenexa Labs Gold Standard
Most peptide sites simply resell vials from overseas labs with little oversight or testing (Much of it is either fake or laced with contaminants). At Cenexa Labs, we manufacture our own peptides under strict USA-based standards…right here IN THE USA. From synthesis to lyophilization to final vial, every step is handled under our direct control — so you never have to question what you’re getting.
We might not be the cheapest, but you can count on our peptides being 100% legit and free from contaminants, heavy metals and toxins.
Why Researchers Choose Cenexa Labs
- End-to-End Chain of Custody: Every batch is logged, tested, and traceable — no middlemen, no relabeling, no guesswork.
- Lot-Linked COAs: Each vial’s lot number ties directly to third-party HPLC/MS results. No recycled or generic COAs.
- We’re the Manufacturer: Because we produce in-house, we control purity, potency, and compliance — instead of reselling from anonymous overseas labs.
- Verified Purity, Every Time: 99%+ purity confirmed on every batch by independent labs, not just claimed on a label.
- GMP-Aligned, USA Based: Manufactured domestically in controlled GMP, ISO 9001-audited facilities.
- Fast, Reliable Fulfillment: Orders placed by 2pm CST ship the same business day. Free USPS Priority on orders $300+. $9.95 Flat rate shipping on all other orders with 2-3 day delivery.
- Backed by Trust: Over 18,000 researchers nationwide rely on Cenexa Labs for consistent, verifiable peptides.
- Room Temperature (Unmixed): Lyophilized (powder) peptides are stable for 3–4 months at room temperature if kept sealed and away from direct light.
- Freezer (Unmixed): For long-term storage, place vials in a freezer. Depending on temperature, peptides can remain stable for 1–3 years.
- After Reconstitution: Once mixed with bacteriostatic water, peptides must be stored in the refrigerator and remain stable for up to 30 days.
All Cenexa peptides are manufactured 100% end-to-end here in the USA using the Lyophilization (Freeze Drying) process. This ensures maximum stability and quality.
Best Practice:
Only reconstitute your peptides when you’re ready to begin using them. Until then, keep vials in their lyophilized powder form, stored in the freezer and away from light.
Fast Processing: We strive to ship same-day. During high-volume times it may take 2–3 days for your package to enter the mailstream. (You’ll see a notice at checkout and can upgrade if you need guaranteed same-day shipping.)
- Flat Rate Shipping: $9.95 on all orders (USPS Priority Mail 2–3 days).
- Free Shipping: Orders over $300 ship free.
- Expedited Options: Faster methods available at checkout.
Important: Orders paid by eCheck won’t ship until payment clears our bank (usually 2–3 business days after it leaves your account).
All products are carefully packaged for safe arrival.
Need help with your order or delivery?
- Call us at +1 800 123 4567
- [email protected]
See What Some Of Our 18,000+ Happy Customers Have To Say…
Related products
-
Peptides
BPC-157 + TB-500 Blend
Price range: $89.99 through $134.99 Select options This product has multiple variants. The options may be chosen on the product page -
Peptides
Kisspeptin-10
$59.99 Select options This product has multiple variants. The options may be chosen on the product page -
Peptides
Ipamorelin
Price range: $43.99 through $64.99 Select options This product has multiple variants. The options may be chosen on the product page -
Peptides
IGF-1 DES
$74.99 Select options This product has multiple variants. The options may be chosen on the product page
